Treatment of Recurrent Hepatitis C Genotype-4 Post- Liver Transplantation with Sofosbuvir plus Simeprevir

Mustafa Ascha, Mona Ascha, NN Zein, N Alkhouri, B Eghtesad, K Abu-Elmagd, T Diago, IA Hanouneh


Hepatitis C virus (HCV) infection remains a leading indication for orthotopic liver transplantation (OLT) worldwide. Recurrence of HCV following OLT is universal. There is scarcity of data on the post-OLT treatment of HCV genotype-4—the predominant genotype in North Africa and the Middle East. Herein, we present three patients who have experienced HCV genotype-4 recurrence post-OLT. All three patients were interferon-naive and were treated with simeprivir (SIM) and sofosbuvir (SOF) combination therapy for 12–24 weeks. The data from this case series show that SIM+SOF are well-tolerated and effective for achieving viral clearance in HCV genotype-4 post-OLT patients. Given the limited nature of a case series, further research must be pursued regarding post-OLT HCV genotype-4 responses to direct-acting anti-viral therapy.


Hepacivirus; Liver transplantation; Genotype; Interferon

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 pISSN: 2008-6482
 eISSN: 2008-6490


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