Evaluation of Cytomegalovirus Infection after Six Months of Liver Transplantation in Children in Shiraz, Southern Iran

N Honar, MH Imanieh, SM Dehghani, M Haghighat, B Geramizadeh, R Yaghobi, A Alborzi, M Ziaeian, K Kazemi, S Nikeghbalian, A Bahador, H Salahi, SA Malek-Hosseini


Background: Liver transplantation (LT) is a life-saving treatment for end-stage liver diseases (ESLD). Cytomegalovirus (CMV) infection is one of the important causes of morbidity after LT.

Objective: To evaluate the incidence of late-onset (after 6 months of LT) CMV infection in pediatric recipients.

Methods: A retrospective analysis was conducted to evaluate 50 pediatric patients who underwent LT for 8 years at the LT Unit of Nemazee Hospital affiliated to Shiraz University of Medical Sciences, Shiraz, Iran. We retrospectively investigated episodes of CMV infection after 6 months of LT proven by CMV antigenemia test.

Results: Three recipients (6%) developed late-onset CMV infection. These patients finally responded to ganciclovir.

Conclusion: CMV infection is one of the most common post-LT viral infections that usually occurs in the first six months of LT. Our study shows that the incidence of late-onset CMV infection is relatively low, but it still remains a significant problem. Therefore, monitoring and management is crucial for improving the survival of children.


Children; Liver transplantation; Late-onset cytomegalovirus infection

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 pISSN: 2008-6482
 eISSN: 2008-6490


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