http://www.ijotm.com/ojs/index.php/IJOTM/issue/feedInt J Organ Transplant Med (IJOTM)2024-02-03T12:55:39+0330Seyed Ali Malek-Hosseiniijotm.ir@gmail.comOpen Journal Systems<img src="/ojs/public/journals/1/IJOTMTopRibon.jpg" alt="" /><img style="float: right; vertical-align: top;" src="/ojs/public/journals/1/IJOTMCover.png" alt="" width="200" align="right" hspace="20" vspace="5" /><span style="color: #a47519; font-family: verdana; font-size: 12pt; line-height: 120%;">This quarterly medical journal is the official Publication of Iranian Society for Organ Transplantation and Avicenna Organ Transplantation Institute.</span><p><span style="color: #a47519; font-family: verdana; font-size: 12pt; line-height: 120%;">Indexed in <em style="font-style: italic;"><a title="View articles in PubMed" href="http://www.ncbi.nlm.nih.gov/pubmed?term=2008-6482[is]" target="_blank">PubMed Central</a>; </em><em>Clarivate Analytics</em> (formerly ISI) <em style="font-style: italic;">Web of Science: Emerging Sources Citation Index (ESCI); Scopus; EMBASE/Excerpta Medica; EBSCO; CINAHL; ISC; Ulrichs Global Serials Directory; </em><em style="font-style: italic;">DOAJ; </em>and<em style="font-style: italic;"> Index Medicus for the EMR</em><em style="font-style: italic;">.</em></span></p><hr />http://www.ijotm.com/ojs/index.php/IJOTM/article/view/1039Host miRNA polymorphisms in viral induced hepatocellular carcinoma outcomes: A common disease underlying liver transplantation2024-02-03T12:55:08+0330Afsoon Afshariafsafshari@yahoo.commohammad hossein karimikarimi70@yahoo.comRamin Yaghobirayaviro@yahoo.com<p>Persistent infections caused by either hepatitis B virus (HBV) and/or hepatitis C virus (HCV) are the principal etiologies of cirrhosis on a global scale, with the potential to progress to the development of hepatocellular carcinoma (HCC). Typically, for HCC detected in its early stages, liver transplantation (LT) represents the optimal therapeutic intervention, as it addresses both the malignancy and the associated liver ailment in a concurrent manner<span style="text-decoration: underline;">.</span> MicroRNAs (miRNAs) are 18-25 nucleotide RNA molecules that are known for their regulating ability during various developing processes of each cell and tissue especially in multicellular organisms. Considering the regulatory potential of miRNAs, any alterations in their expression pattern such as mutations that produce single-nucleotide polymorphisms (SNPs), might cause anomalies like tumors. In this review manuscript a systematic approach was used to investigate the studies performed to evaluate the role of Host miRNA SNPs in the outcome of viral based (HBV and HCV) HCC. The search was directed in PubMed, Web of Science, and Scopus databases that resulted in 33 related original articles and 8 reviews that used for finding any missing reports. Therefore, in this review it is tried to discuss the importance and relation of SNPs in host miRNAs during viral induced HCC complications.<strong></strong></p>2024-02-03T12:55:11+0330Copyright (c) 2024 Int J Organ Transplant Med (IJOTM)http://www.ijotm.com/ojs/index.php/IJOTM/article/view/786Point shear wave Acoustic radiation force impulse elastography (pSW-ARFI) is A Noninvasive Tool to Diagnose Acute and Chronic Hepatic Graft-Versus-Host Disease in adult Patients Undergoing allogeneic HSCT.2024-02-03T12:55:08+0330walaa elsalakawydrwalaa2010@gmail.comamal elafifiamalelafifi_24@hotmail.comYasser El HosaryElHosary234@gmail.cpmhaydi Sayed Mohamedhaydisayed@hotmail.com<p><strong>Purpose</strong>: The gold standard method of diagnosis of hepatic GVHD is liver biopsy. However, liver biopsy is an invasive procedure with risk of complications especially bleeding. ARFI imaging is a non-invasive, sensitive, and accurate tool for the assessment of liver fibrosis during routine conventional US evaluations.</p><p><strong>Methods</strong>: The study was conducted prospectively on 30 adult patients undergoing allogeneic HSCT. pSW-ARFI elastography (stiffness and score) was performed for all patients: pre-transplant, within 3- and 6-months post-transplant. </p><p><strong>Results: </strong> ARFI score and stiffness were higher in patients who developed acute hepatic GVHD in comparison to those who did not develop aGVHD (P-value= 0.028 and 0.03 respectively).Furthermore, the mean ARFI stiffness during the 1<sup>st</sup> 3 months s post-transplant was directly correlated to the grade of acute hepatic GVHD (P-value= 0.012). Moreover; ARFI score and stiffness within 6 months post-transplant were higher in patients who developed chronic hepatic GVHD in comparison to those who did not develop (p-value= 0.020 and 0. 018 respectively). </p><p><strong>Conclusions</strong>: pSW-ARFI is a reliable non-invasive tool for the early diagnosis of acute and chronic hepatic GVHD especially if a liver biopsy is not feasible. It can also be used in the grading of acute hepatic GVHD.</p>2024-02-03T12:55:11+0330Copyright (c) 2024 Int J Organ Transplant Med (IJOTM)http://www.ijotm.com/ojs/index.php/IJOTM/article/view/871Evaluation the prevalence of gastrointestinal lesions and Helicobacter pylori infection in upper endoscopic study of asymptomatic renal transplantation candidates2024-02-03T12:55:08+0330Ladan goshayeshigoshayeshil@mums.ac.irkatayoun samadisamadik@mums.ac.irmohammad samadidr.mohamadsamadi@gmail.comAbbas-ali Zeraatizeraatia@mums.ac.iralireza khoyikhoyia@mums.ac.irsaeed akhlaghiakhlaghis@mums.ac.irtina zeraatitina_ze74@yahoo.comzahra kazemikazemiaty1@gmail.com<p>Introduction: Renal transplantation is the most effective therapeutic strategy in ESRD patients. One of the post renal transplantation complications is gastrointestinal bleeding due to peptic ulcers as well as other upper gastrointestinal diseases which have a great impact on patients’ morbidity and mortality. The present research aims to shed light on prevalence of gastrointestinal lesions and Helicobacter pylori infection in asymptomatic candidate for renal transplantation using upper endoscopy.</p><p>Materials and Methods: The present cross-sectional research was performed on 85 renal transplant candidates referred to organ transplantation center within 2016 to 2018. Patients who met inclusion criteria and didn’t have exclusion criteria underwent upper endoscopy and were classified according to endoscopic findings, Helicobacter pylori infection and pathologic findings.</p><p>Results: 53 patients (62%) had significant endoscopic findings. Erosive gastroduodenitis (32.5%) was the most common finding . 73% of patients had abnormal pathologic findings and Helicobacter pylori infection was seen in 48.2%. Significant correlation was found between H. Pylori infection and abnormal pathology (p=0.04) .</p>Conclusion: Our findings showed that asymptomatic gastrointestinal lesions and Helicobacter pylori infection were significant in renal transplantation candidates thus routine upper endoscopy is recommended in pre-transplant patients in order to detect and treat gastric lesions before kidney transplantation to prevent serious complication after transplantation2024-02-03T12:55:11+0330Copyright (c) 2024 Int J Organ Transplant Med (IJOTM)http://www.ijotm.com/ojs/index.php/IJOTM/article/view/883Comparison of the efficacy of tadalafil in three different groups: patients on hemodialysis, first kidney transplant recipients, and second kidney transplant recipients2024-02-03T12:55:08+0330Mehdi Dehghanimdeh61@gmail.comAmir-Hesam Alirezaeiamirhesam021@gmail.comAmir Javidamirjavid2000@yahoo.comNasrin BorumandniaBorumand.n@gmail.comMajid Ali AsgariMajeed_Asgary@Yahoo.comFarshad Gholipourfarshad.gholipoor@gmail.com<p><strong>BACKGROUND: </strong>The efficacy of phosphodiesterase-5 inhibitors (PDE5Is) on the improvement of erectile dysfunction (ED) in second kidney transplant (KT) recipients has not been well investigated previously. </p><p><strong>OBJECTIVE: </strong>We aimed to compare the efficacy of tadalafil in three groups: hemodialysis (HD) patients, first KT recipients (KT1), and second KT recipients (KT2) with bilaterally ligated internal iliac arteries. </p><p><strong>METHODS: </strong>Age-matched men with erectile dysfunction were included in the study. Patients had been divided into three groups: HD, KT1, and KT2. The International Index of Erectile Function 15 (IIEF-15) was used to assess baseline erectile function. Tadalafil was administered in a dose-escalation method for three months. Patients were reevaluated by the questionnaire at 3 months. The mean score evolution was compared between the study groups by one-way ANOVA test. </p><p><strong>RESULTS: </strong>Total number of 106 patients in three groups was included in the final analysis. There was no significant difference between the study groups in terms of age, body mass index (BMI), blood pressure, and frequency of smoking, opium, or alcohol use. Tadalafil was safe and effective in all three groups. The mean IIEF score evolution in HD, KT1, and KT2 groups was 16.4 (58.7% increase from baseline), 19.3 (45.0% increase), and 20.4 (52.7% increase), respectively (p=0.66). </p><p><strong>CONCLUSIONS:</strong> Tadalafil is effective and safe in the management of ED after the second kidney transplantation where the internal iliac arteries are cut bilaterally. The response rate is similar to first kidney transplant recipients and hemodialysis patients.</p>2024-02-03T12:55:11+0330Copyright (c) 2024 Int J Organ Transplant Med (IJOTM)http://www.ijotm.com/ojs/index.php/IJOTM/article/view/1035Comparison of health anxiety levels and quality of life of living donors before and after liver transplant surgery: A cross sectional study2024-02-03T12:55:11+0330Mohammad-Ali SahmeddiniSahmeddini@sums.ac.irEsmaeil Sarikhani-KhorramiSarikhani.e@gmail.comNegar shahkaraminegar.shahkarami@yahoo.comesmaeil kaviKavi.esmaeil@gmail.comEsmaeil Kargar-DoulatabadiEsmaeil.kargarda@gmail.comHadi ShafieiKasra_medicine87@yahoo.comLeila Ahmadi-Larielnaz_ahmadi71@yahoo.comZeinab Yazdanizeinab.yz899141@yahoo.comAsghar EmamiSepehremami70@gmail.comAlireza GhanbariAlinurse1371@gmail.com<p><strong>Background: </strong>Partial liver transplantation is one of the standard methods for liver transplantation. This surgical procedure is performed from a living person to a sick person, which can lead to physical and mental challenges affecting the quality of life of donors.</p><p><strong>Objective:</strong> To compare the level of health anxiety and quality of life of liver donors before and after liver transplant surgery.<strong></strong></p><p><strong>Methods: </strong>This descriptive cross-sectional study was performed on 45 liver donor patients referred to Shiraz Organ Transplant Hospital. Standard questionnaires of demographic information, health anxiety and quality of life were used to collect data. Descriptive and inferential statistics tests were used to analyses the data.</p><p><strong>Results: </strong>Patients' quality of life score (in comparison with the overall score and with the subgroups) decreased significantly (p = 0.001) after liver donation. Also, patients' health anxiety scores (in comparison with the overall score and with the subgroups) increased significantly after surgery (p = 0.001).</p><p><strong>Conclusion: </strong>The implementation of awareness programs before and after surgery and purposeful and long-term follow-up, as well as the use of empowerment programs to increase the level of health and quality of life of these people can be a comprehensive and appropriate approach for hospital officials in order to improve health and quality of life after organ donation.</p><p> </p>2024-02-03T12:55:11+0330Copyright (c) 2024 Int J Organ Transplant Med (IJOTM)http://www.ijotm.com/ojs/index.php/IJOTM/article/view/1067Successful treatment of primary central nervous system post-transplant lymphoproliferative disorder after liver transplant using methotrexate: A Novel Case Report2024-02-03T12:55:08+0330Kyle Jon Scholtenkscholten@unmc.eduJason Barbarettajbarbaretta@unmc.eduKevin Brittankbrittan@unmc.eduPatrick Twohigpatrick.twohig@unmc.eduFaruq Pradhanfpradhan@unmc.eduNeha Guptanegupta@unmc.eduTomoki Sempokuyatomoki.sempokuya@unmc.eduWuttiporn Manatsathitshane.manatsathit@unmc.edu<p>Post-transplant lymphoproliferative disorder (PTLD) is a malignancy that occurs in 2-20% of solid organ transplant recipients. Isolated, primary central nervous system (PCNS) PTLD is exceedingly rare, with existing data limited to case reports and case series. The diagnosis of PCNS PTLD is difficult to diagnose given 1) non-specific clinical presentation and 2) burden of immunosuppression broadens diagnostic possibilities, often requiring extensive testing to reach a definitive diagnosis. We present the first known case of isolated PCNS PTLD after liver transplantation safely treated with methotrexate. Our case highlights the complex diagnostic and treatment considerations in the setting of immunosuppression and maintenance of adequate graft function.</p>2024-02-03T12:55:12+0330Copyright (c) 2024 Int J Organ Transplant Med (IJOTM)