The Impact of Hepatitis B Infection on Outcome of Kidney Transplantation: A Long-Term Study

B Einollahi, S M Alavian, M Lessan-Pezeshki, N Simforoosh, M H Nourbala, Z Rostami, V Pourfarziani, E Nemati, M Sharafi, M Nafar, F Pour-Reza Gholi, A Firoozan


Background: With the success of kidney transplantation, liver disease has emerged as an important cause of morbidity and mortality in kidney recipients.

Objective: To determine the impact of hepatitis B virus (HBV) infection on patients and graft survival in both short- and long-terms.

Methods: 99 renal transplant patients infected with HBV on follow-up in two major transplant centers were included in a retrospective study. These patients were grafted between 1986 and 2005 and divided into two groups: (1) those only positive for hepatitis B surface antigen (HBsAg) and (2) those who were also positive for hepatitis C virus antibodies (HCV Ab).

Results: There were 88 patients with HBsAg+ and 11 with both HBsAg+ and HCV Ab+. The mean±SD age of patients was 38.8±13.2 years, and the median follow-up after transplantation was 19 months. Although not significant, the allograft survival rate in the first group (HBV+) was better compared to that in the second group (HBV+ and HCV+); 1, 5 and 10 years graft survival rates were 91, 77 and 62 in the first group and 70, 56 and 28 in the second group, respectively (P=0.07). The overall mortality was 5% (4 of 88) in the first and 27% (3 of 11) in the second group (P=0.02).

Conclusion: Renal allograft recipients with HBV and HCV infections has a poor survival rate compared to patients with only HBV infection. However, there is no significant difference in terms of renal graft survival between the two groups.


Kidney transplantation; Hepatitis B virus; Hepatitis C virus

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 pISSN: 2008-6482
 eISSN: 2008-6490


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